Search results for " HUMAN IDENTIFICATION"

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In silico and in vitro comparative analysis to select, validate and test SNPs for human identification.

2007

Abstract Background The recent advances in human genetics have recently provided new insights into phenotypic variation and genome variability. Current forensic DNA techniques involve the search for genetic similarities and differences between biological samples. Consequently the selection of ideal genomic biomarkers for human identification is crucial in order to ensure the highest stability and reproducibility of results. Results In the present study, we selected and validated 24 SNPs which are useful in human identification in 1,040 unrelated samples originating from three different populations (Italian, Benin Gulf and Mongolian). A Rigorous in silico selection of these markers provided …

Asialcsh:QH426-470lcsh:BiotechnologyIn silicoPolymorphism Single Nucleotide; Heterozygote Detection; Gene Frequency; Humans; Africa; Europe; Computational Biology; Sequence Analysis DNA; Forensic Anthropology; Asia; Chromosome MappingSingle-nucleotide polymorphismBiologyHeterozygote DetectionGenomePolymorphism Single NucleotideGene Frequencylcsh:TP248.13-248.65GeneticsHumansPolymorphismAllele frequencySelection (genetic algorithm)GeneticsGenetic Carrier ScreeningChromosome MappingComputational BiologySingle NucleotideDNASequence Analysis DNAHuman geneticsEuropelcsh:GeneticsSettore MED/03 - Genetica MedicaAfricaSNPs HUMAN IDENTIFICATION comparative analysisForensic AnthropologyHuman genomeDNA microarraySequence AnalysisBiotechnologyResearch ArticleBMC genomics
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